| Certification: | GMP |
|---|---|
| Grade Standard: | Medicine Grade |
| State: | Solid |
| Volatile: | Not Volatile |
| Transport Package: | 1kg/5kg/10kg/25kg |
| Specification: | 1kg/5kg/10kg/25kg |
| Samples: |
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| Customization: |
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| DOBUTAMINE HYDROCHLORIDE Chemical Properties |
| Melting point | 184-186 C |
| storage temp. | 2-8°C |
| solubility | Sparingly soluble in water, soluble in metha nol, sparingly soluble in ethanol (96 per cent). |
| form | neat |
| pka | 9.45(at 25ºC) |
| Water Solubility | Soluble in water or ethanol with warming. Also soluble in meth anol |
| λmax | 281nm(MeOH)(lit.) |
| Merck | 14,3395 |
| CAS DataBase Reference | 49745-95-1(CAS DataBase Reference) |
| EPA Substance Registry System | 1,2-Benzen ediol, 4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-, hydrochloride (49745-95-1) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 20/21/22-63-36/37/38-R63-R62-R11-R21-R20 |
| Safety Statements | 22-26-36/37/39-36/37-S53-S39-S37-S36-S26-S22 |
| WGK Germany | 3 |
| HS Code | 29222990 |
| Toxicity | LD50 i.v. in mice: ~73 mg/kg (Weber, Tuttle) |
| DOBUTAMINE HYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | White to Off-White Solid |
| Uses | analeptic |
| Uses | Dobutamine Hydrochloride is a sympathomimetic drug used to treat heart failure by inhibiting β1 receptors in the sympathetic nervous system. Cardiotonic. |
| Definition | ChEBI: The hydrochloride salt of dobutamine. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used to increase the contractility of the heart in the m nagement of acute heart failure. |
| Brand name | Dobutrex (Lilly). |
| Biological Activity | β 1 - and β 2 -adrenoceptor agonist with some action at the α 1 -adrenoceptor. |
| Veterinary Drugs and Treatments | Dobutamine is used as a rapid-acting injectable positive inotropic agent for short-term treatment of heart failure. It is also useful in shock patients when fluid therapy alone has not restored acceptable arterial blood pressure, cardiac output, or tissue perfusion. |
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